<i>In vivo</i>immune inhibitory role of Ly-6A protein
نویسندگان
چکیده
Abstract Ly-6A is a GPI-anchored cell surface protein with reported adhesion and signaling role in CD4 +T cells. shows low expression on naïve T cells; however, its elevated upon activation. Additionally, IFN-γ IL-27 cytokines increase expression, feature observed immune checkpoint inhibitory (ICI) proteins, such as PD-1 CTLA-4. Many reports using lines primary cells show, for ICI inhibiting clonal expansion of antigen receptor-stimulated While the published vitro ex vivo studies provide strong evidence protein, unknown. Using tumor transplantation mouse model, we have found that Ly-6A-deficient mice support slower or no growth B16-F10 melanoma MC38 adenocarcinoma tumors compared to wildtype C57BL/6 control mice. We report injected number activated draining lymph nodes (DLN) day-3 post-injection. Furthermore, significantly proliferation DLN from was day-7, assessed by assays. Transcriptome analyses tissues showed, among others, inducible chemokine genes. CD73 confocal microscopy, lower than tumors. Our results reveal novel potential target cancer immunotherapy, either standalone combinatorial blockade strategy. Supported funds Department Biology, Villanova University (SRG) & Sigma Xi
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.89.23